- Title
- Investigation of serum bactericidal activity in childhood and adolescence 3-6 years after vaccination with a single dose of serogroup C meningococcal conjugate vaccine
- Creator
- Sakou, Irine-Ikbale; Tzanakaki, Georgina; Kremastinou, Jenny; Tsolia, Maria N.; Sioumala, Maria; Barbouni, Anastasia; Kyprianou, Miltiades; Papaevangelou, Vana; Tsitsika, Artemis; Blackwell, Caroline C.; Kafetzis, Dimitris
- Relation
- Vaccine Vol. 27, Issue 33, p. 4408-4411
- Publisher Link
- http://dx.doi.org/10.1016/j.vaccine.2009.05.047
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2009
- Description
- Serogroup C meningococcal conjugate vaccines were introduced in Greece in 2001, and although no cases of serogroup C meningococcal disease were recorded in 2004, a steady increase was observed since 2005. In this study, serum bactericidal activity was assessed in sera of 269 vaccinated children at a mean time of about 5 years after vaccination. Non-protective antibody titers were observed in most children vaccinated at age <6 years (85.9%), followed by those between 6 and 10 years (62.2%). This percentage was considerably lower in adolescents vaccinated at an age >10 years (37.8%) (p < 0.01). Geometric mean concentrations of serum IgG antibodies against serogroup C showed a similar variation. The results indicate that serum bactericidal antibody titers significantly correlate with age of vaccination; most children do not have protective antibody titers few years after immunization in infancy and childhood whereas most adolescents maintain sustained protection.
- Subject
- MenC vaccine; bactericidal activity; children; adolescence
- Identifier
- http://hdl.handle.net/1959.13/807047
- Identifier
- uon:7296
- Identifier
- ISSN:0264-410X
- Language
- eng
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